Paraformaldehyde (PFA) 8 %, in PBS pH 7.2
An 8% paraformaldehyde solution (PFA) in phosphate-buffered saline (PBS) with a pH of 7.2 is a ready-to-use fixing solution used in biological and histological studies.
Paraformaldehyde is a polymer of formaldehyde that depolymerizes to formaldehyde in water. Formaldehyde acts as a strong fixative that cross-links proteins and nucleic acids in tissues and cells, thereby preserving cellular structure and morphology. An 8% paraformaldehyde solution provides a high enough concentration of fixative to ensure effective fixation of tissue samples.
Phosphate-buffered saline (PBS) is a commonly used buffer solution in biological research settings that stabilizes pH and maintains osmotic conditions in biological samples. PBS, with a pH of 7.2, is close to the physiological pH commonly found in cells and tissues and helps maintain the sample in a stable state during fixation.
The 8% paraformaldehyde solution in PBS pH 7.2 is often used in immunohistochemistry, electron microscopy and fluorescence microscopy to fix and preserve cells and tissues for examination under the microscope. Fixation with paraformaldehyde helps maintain the integrity of cellular structure and the binding of antibodies and fluorochromes during staining and analysis.
Paraformaldehyde is a polymer of formaldehyde that depolymerizes to formaldehyde in water. Formaldehyde acts as a strong fixative that cross-links proteins and nucleic acids in tissues and cells, thereby preserving cellular structure and morphology. An 8% paraformaldehyde solution provides a high enough concentration of fixative to ensure effective fixation of tissue samples.
Phosphate-buffered saline (PBS) is a commonly used buffer solution in biological research settings that stabilizes pH and maintains osmotic conditions in biological samples. PBS, with a pH of 7.2, is close to the physiological pH commonly found in cells and tissues and helps maintain the sample in a stable state during fixation.
The 8% paraformaldehyde solution in PBS pH 7.2 is often used in immunohistochemistry, electron microscopy and fluorescence microscopy to fix and preserve cells and tissues for examination under the microscope. Fixation with paraformaldehyde helps maintain the integrity of cellular structure and the binding of antibodies and fluorochromes during staining and analysis.
Article no.: 12457
Fixation of tissue samples
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UN-Nummer: 0000
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Lagerung: 4 … 8 °C
Haltbarkeit: 10 Tage
product information
Relevant Ingredients:
• Paraformaldehyde
• PBS Buffer pH 7.2 - 10x concentrate
• Sodium hydroxide solution / NaOH 1.0 mol/l
Hazard and safety instructions
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