Formaline 4 %, unbuffered
Formalin 4%, unbuffered, is an aqueous solution of 4% formaldehyde used as a fixative in histology and pathology. Formaldehyde is a strong aldehyde that forms covalent bonds with proteins and nucleic acids in tissue specimens. This leads to stabilization of cellular structures and prevents cell decay and autolysis that can occur during processing of tissue samples.
Unbuffered formalin solution is often injected directly into tissue samples or used as a bath in which samples are placed for a period of time. Fixation with formalin preserves cellular morphology and allows detailed examination of cell structures and tissue architecture. However, unbuffered formalin can result in a more acidic environment, which can lead to some distortion of cellular structures and staining characteristics. Therefore, buffered formalin is preferred in many cases, which stabilizes the pH by the addition of buffer solutions such as phosphate buffer, thus ensuring better fixation of the samples.
Unbuffered formalin solution is often injected directly into tissue samples or used as a bath in which samples are placed for a period of time. Fixation with formalin preserves cellular morphology and allows detailed examination of cell structures and tissue architecture. However, unbuffered formalin can result in a more acidic environment, which can lead to some distortion of cellular structures and staining characteristics. Therefore, buffered formalin is preferred in many cases, which stabilizes the pH by the addition of buffer solutions such as phosphate buffer, thus ensuring better fixation of the samples.
Article no.: 11711
Fixation of tissue samples
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UN-Nummer: 0000
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Lagerung: 15 … 25 °C
Haltbarkeit: 24 Monate
Instructions / Protocol / Recommendations
Verwendung:
Bei der Fixierung werden alle in der Zelle ablaufenden Prozesse unterbrochen, unter möglichst optimaler Erhaltung des Zustandes und der Struktur des Gewebes. Biochemische Prozesse wie Autolyse, Verwesung und Fäulnis werden wirkungsvoll verhindert. Fixierlösung nach Stieve eignet sich zur Fixierung von Hodengewebe und Eierstockgewebe. Die Fixierlösung ist ausschließlich für die professionelle Anwendung als in-vitro Diagnostikum im histologischen Labor vorgesehen.
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